Wound healing proceeds in several phases – hemostasis, inflammation, proliferation and maturation. The whole process is controlled on both local and systemic level. 
Wound healing in diabetic patients is complicated by local changes of mediators (change of growing factors, extracellular matrix, enzymes), different cellular activity and granular tissue formation, bacterial or mycotic infections, higher prevalence of peripheral vascular disease and higher production of ROI (reactive oxygen intermediates). Healing is controlled by both already mentioned local factors and systemic factors, e.g. control of diabetes mellitus, capacity of immune system and nutritional status.

Key words: wound healing, diabetes mellitus, local and systemic factors of wound healing