Hyaluronic acid (HA), which chemically belongs to the family of glycosaminoglycans, is an essential part of an extracellular matrix. It significantly contributes to the process of tissue reparation and it modulates individual phases of wound healing. It participates in both inflammatory and granulation phase, it supports the epithelization and remodelation of tissues. Bionect (gauze pads and cream) containing hyaluronic acid sodium salt represents a new bandage for the treatment of both acute and chronic wounds. The following article describes a study that assessed the efficacy of Bionect in the treatment of both acute and chronic wounds of a different etiology. Study results showed that Bionect significantly improved the healing of both acute and chronic uninfected wounds. Additionally, following the application the pain quickly relieves, which improves patients’ quality of life. Bionect positively affects the final state of a scar – hyaluronic acid reduces excessive collagen, which leads to a reduced scarring.

Key words: hyaluronic acid, wound healing, quality of life

Acne is a non-infective chronic inflammatory disease of sebaceous glands and hair follicles. It affects a pilosebaceous unit, which is unique only in humans. 80–100 % of adolescents at the age of 11–25 years are affected by symptoms of acne and in 10–15 % of patients the symptoms develop even later.
The paper describes a case of a 17years old boy. He has been followed-up and treated for acne with progressive bone and articular impairment since 2006. He improved after combined systemic corticosteroid and retinoid treatment followed by skin transplantation on his chest.

Key words: pilosebaceous unit, acne comedonica, acne papulopustulosa, acne conglobata, SAPHO syndrome

Using transcutaneous oxymetry with transcutaneous partial pressure of oxygen measurement (TcPO₂) we monitored changes in skin microcirculation above sacrum during positioning on different types of antidecubital bases. The best antidecubital action quantitated by maximal TcPO₂ values during supine position achieved the multicomponent mattress Tempur (median of TcPO₂ 52 mmHg). An airbed was even less effective and foam ruber mattress, polyester base and base with polypropylenic filling demonstrated insufficient antiischemic effect. Also the most effective mattress Tempur failed in 4 investigated persons (18 %), when TcPO₂ value in supine position was less than 30 mmHg. These results clearly show that despite the progress in quality of antidecubital tools, periodical positioning for bedsores prevention is still necessary.

Key words: decubitus, transcutaneous oxymetry, antidecubital bases, microcirculation disorders

The application of negative pressure in the treatment of infective wounds comes into use not only in surgical, traumatological and orthopedic departments, but we find its indications also in plastic, particularly reconstructive surgery and in the burn treatment. Although there are several modifications of negative pressure therapy available in the Czech Republic nowadays, in our department – the Clinic of Burn and Reconstructive Surgery in Brno – we mastered the use of the V.A.C. system (i.e. Vacuum Assisted Closure) years ago. As the use of this system is very wide I would like to share a few comments on its use in our specialization. We collected (unfortunately substantially nonhomogenic) group of more than 200 patients with various defects.

Key words: negative pressure therapy, decubituses, burns